The MLE estimator is normally distributed asymtotically: \[\hat{\theta} \sim AN(\theta, \frac{1}{I(\theta)})\]
Definition of the Fisher Information Matrix, also called curvature matrix:
\[ \begin{aligned} I(\theta) &= E[\frac{\partial}{\partial\theta} \mathcal{l}(\theta)]^2 \\ &= -E[\frac{\partial^2}{\partial^2\theta} \mathcal{l}(\theta)] \\ \end{aligned} \]
\(\Rightarrow\) The asymtotic covariance matrix of \(\hat{\theta}_{MLE}\):
\[
\begin{aligned}
Var(\hat{\theta}_{MLE}) &\approx -E[\frac{\partial^2Log\mathcal{l}(\theta)}{\partial\theta \ \partial\theta^T}]^{-1} \\
&= E[\frac{\partial Log\mathcal{l}(\theta)}{\partial \theta} \cdot (\frac{\partial Log\mathcal{l}(\theta)}{\partial \theta})^T]
\end{aligned}
\]